Menene tsarin sodium thiosulfate wajen magance guba na cyanide?

Gubar Cyanide cuta ce mai tsanani kuma mai barazana ga rayuwa wadda ke buƙatar kulawar likita nan take. Sodium thiosulfate yana ɗaya daga cikin manyan magunguna da ake amfani da su wajen magance Gubar Cyanide . Wannan labarin zai binciki cikakken tsarin yadda Sodium Thiosulfate ke aiki don magance tasirin cyanide.

Fahimtar Gubar Cyanide

Cyanide abu ne mai guba sosai. Lokacin da ya shiga cikin jiki, da sauri ya rabu zuwa cikin ions cyanide (CN⁻). Wadannan ions suna da alaƙa mai girma ga ferric ion (Fe³⁺) a cikin cytochrome oxidase, wani enzyme mai mahimmanci don numfashi ta salula. Ta hanyar ɗaure zuwa cytochrome oxidase, cyanide yana hana sarkar jigilar lantarki, yana hana sel yin amfani da iskar oxygen yadda ya kamata. A sakamakon haka, sel ba su iya samar da adenosine triphosphate (ATP), kudin makamashi na tantanin halitta, wanda ke haifar da mutuwar kwayar halitta da sauri. Alamomin guba na cyanide na iya haɗawa da ciwon kai, tashin hankali, saurin numfashi, tashin zuciya, amai, kuma a cikin yanayi mai tsanani, asarar hayyacinta, kamawa, da mutuwa.

Matsayin Sodium Thiosulfate a Jiyya

Kayan aikin

Sodium thiosulfate yana aiki azaman mai ba da gudummawar sulfur. A gaban enzyme rhodanese, wanda yake a cikin hanta da sauran kyallen takarda, sodium thiosulfate yana amsawa tare da ions cyanide. Atom ɗin sulfur daga sodium thiosulfate ana canja shi zuwa ion cyanide, yana mai da shi zuwa thiocyanate (SCN⁻). Thiocyanate ba shi da guba sosai fiye da cyanide kuma ana iya fitar da shi cikin aminci daga jiki ta cikin kodan.

Ana iya wakilta halayen sinadaran kamar haka:

CN⁻ + Na₂S₂O₃ → SCN⁻ + Na₂SO₃

Wannan tsarin jujjuyawar yana taimakawa wajen rage yawan ion cyanide mai guba a cikin jiki, yana barin numfashin salula na yau da kullun ya dawo.

Gudanarwa a Jiyya

Lokacin maganin guba na cyanide, sodium thiosulfate yawanci ana gudanar da shi ta cikin jini. A cikin manya, kashi na farko na kowa shine 12.5 - 25 grams (yawanci a matsayin 25% - 50% bayani). Sau da yawa ana biye da wannan ta hanyar ƙarin allurai kamar yadda ake buƙata, dangane da tsananin guba da martanin mai haƙuri. Misali, a wasu lokuta, ana iya ba da kashi na biyu na gram 25 - 50 (maganin kashi 50%), ko kuma a ƙididdige adadin gwargwadon nauyin jikin majiyyaci a 0.5 - 1 gram a kowace kilogiram na nauyin jiki.

A cikin yara, ana lissafin kashi bisa nauyin jiki, yawanci a 250 - 500 milligrams da kilogram. Ana ba da maganin a hankali don kauce wa yiwuwar illa irin su hypotension (ƙananan jini), wanda zai iya faruwa idan an yi shi da sauri.

Haɗuwa da Sauran Jiyya

Ana amfani da sodium thiosulfate sau da yawa tare da sauran hanyoyin kwantar da hankali don guba na cyanide. Ɗayan haɗuwa da aka fi sani shine tare da nitrites, irin su sodium nitrite ko amyl nitrite. Nitrites suna aiki ta hanyar canza haemoglobin zuwa methemoglobin. Methemoglobin yana da alaƙa mafi girma ga ions cyanide fiye da cytochrome oxidase. Don haka, lokacin da aka samu methemoglobin a cikin jiki, ion cyanide zai fi dacewa da shi, yana sakin cytochrome oxidase kuma yana barin numfashin salula ya sake farawa. Duk da haka, hadadden cyanide - methemoglobin ba shi da kwanciyar hankali, kuma ana iya sake sakin cyanide a cikin jini na tsawon lokaci. Anan ne sodium thiosulfate ke shigowa. Ta hanyar canza cyanide da aka saki daga cyanide - methemoglobin zuwa thiocyanate, sodium thiosulfate yana samar da ƙarin bayani na dogon lokaci don cire cyanide daga jiki.

Baya ga nitrites, ana kuma bayar da wasu jiyya masu tallafi. Waɗannan na iya haɗawa da babban maganin iskar oxygen don haɓaka isar da iskar oxygen zuwa kyallen takarda, da kuma matakan sarrafa alamun kamar su tashin hankali, hauhawar jini, da acid - rashin daidaituwa na tushe waɗanda galibi suna tare da guba na cyanide.

Kulawa da Bibiya

Bayan gudanar da sodium thiosulfate da sauran jiyya na guba na cyanide, marasa lafiya suna buƙatar kulawa sosai. Ma'aikatan kiwon lafiya za su duba mahimman alamun kamar bugun zuciya, hawan jini, yawan numfashi, da isasshen iskar oxygen akai-akai. Ana iya yin gwajin jini don auna matakan cyanide, thiocyanate, da alamomin lalacewar nama. Bugu da ƙari, za a lura da yanayin jijiyar mai haƙuri a hankali, kamar yadda guba na cyanide zai iya haifar da mummunar lalacewa ga tsarin juyayi na tsakiya.

Kulawa da bin diddigi yana da mahimmanci. Ko da majiyyacin ya bayyana ya murmure da farko, za a iya samun sakamako na dogon lokaci kamar nakasar jijiya ko lalacewar gaɓoɓin jiki. Dubawa na yau da kullun da matakan gyara da suka dace na iya zama dole don tabbatar da mafi kyawun sakamako ga mai haƙuri.

A ƙarshe, sodium thiosulfate yana taka muhimmiyar rawa a cikin maganin guba na cyanide ta hanyar canza ions cyanide mai guba mai guba zuwa ƙarancin thiocyanate mai guba. Yin amfani da shi, tare da wasu hanyoyin kwantar da hankali da kuma kulawa mai kyau, na iya inganta yiwuwar rayuwa da farfadowa ga marasa lafiya da ke fama da guba na cyanide.