Description
colorless transparent liquid, with odor of ester. Boiling point 103 -105 °C, Relative Density 0.9676(20/4 °C), Refractive index 1.3773 (2.5 °C), Flash point 15 °C, soluble in ethanol and ether and decomposable in water.
Application
Trimethyl orthoformate is a useful building block for creating methoxymethylene groups and heterocyclic ring systems. It introduces a formyl group to a nucleophilic substrate, e.g. RNH2 to form R-NH-CHO, which can undergo further reactions. It is used in the production of some fungicides (for example: azoxystrobin and picoxystrobin), as well as for some members of the floxacin family of antibacterial drugs.
A number of pharmaceutical intermediates are also made from Trimethyl Orthoformate.
Trimethyl orthoformate is also an effective reagent for converting compatible carboxylic acids to their corresponding methyl esters. Alternatively, acid-catalyzed esterifications with methanol can be driven closer to completion by employing trimethyl orthoformate to convert water byproduct to methanol and methyl formate.
Intermediate for agrochemicals
Intermediate for pharmaceuticals
Specifications
Items | Optimal level | Export level |
Content | ≥99.5% | ≥99.00% |
Methanol | ≤0.2% | ≤0.3% |
Methyl Formate | ≤0.2% | ≤0.3% |
Moisture | ≤0.05% | ≤0.05% |
Free acid (calculated as formic acid) | ≤0.05% | ≤0.05% |
Triazine | ≤0.02% | -- |
Other impurities | ≤0.1 | -- |
Packing specifications
Drums with 200kg weight capacity per drum
Certifications
ISO 9001. ISO 22716. cGMP certified
Kosher, Halal certified
Shipping Information
MOQ: (Due to the nature of chemical transportation, please consult the sea trade manager for details!)
Port of Loading: CHINA - Shanghai Port, Ningbo Zhoushan Port, Guangzhou Port, Qingdao Port, Tianjin Port, Dalian Port, Xiamen Port, Lianyungang Port (can be ensured according to the requirements of customers)
Delivery Time: 4-6 weeks
Payment Terms
L/C, D/P, T/T at buyer’s cost
Sample available on request
Multiple Names
Trimethoxymethane
methoxymethanediol
METHYLFORMIAT-ORTHO
Methyl orthoformate
Trimethylorthoformiat
Trimethyl orthoformate
Thrimethyl orthoformate
Trimethyl ortho formate
orthoformicacidmethylester
TrimethylOrthoFormate(Tmof)
Trimethyl Orthoformate(TMOF)
Orthoformic acid trimethyl ester
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